16,523 research outputs found
Stem Cell Therapeutics: Exploring Newer Alternatives to Human Embryonic Stem Cells
Stem cells therapeutics has come a long way since stem cells and their potential was discovered for the first time.
Intense research into cellular biology of stem cells has revealed that they possess immense potential for curing
many human diseases. Research done in last couple of decades revealed that a particular class of stem cells
called, “Human embryonic stem cells (HESCs)” possessed exceptional self-renewal and pluripotency properties.
There ability to differentiate into specialized cell lineages of all three embryonic germ layers contributed further towards their popularity. However, in recent times HESCs have come under the cross-hairs of critics, politicians and religious groups due to certain technical and ethical concerns related to them. Such problems with HESCs research have forced stem cell researchers to start exploring the prospects of using alternatives to HESCs for
regenerative medicine and therapeutics. In the present review, various sources of stem cells have been described,
which in near future, have the potential to replace HESCs in regenerative medicine
Palladium-catalyzed acetylation of arenes.
A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in synthetically useful yields. The methodology is tolerant of heterocycles and provides a new method for arene functionalization
Optimal cooperative control synthesis of active displays
A technique is developed that is intended to provide a systematic approach to synthesizing display augmentation for optimal manual control in complex, closed-loop tasks. A cooperative control synthesis technique, previously developed to design pilot-optimal control augmentation for the plant, is extended to incorporate the simultaneous design of performance enhancing displays. The technique utilizes an optimal control model of the man in the loop. It is applied to the design of a quickening control law for a display and a simple K/s(2) plant, and then to an F-15 type aircraft in a multi-channel task. Utilizing the closed loop modeling and analysis procedures, the results from the display design algorithm are evaluated and an analytical validation is performed. Experimental validation is recommended for future efforts
Large transverse field tunnel splittings in the Fe_8 spin Hamiltonian
The spin Hamiltonian that describes the molecular magnet Fe has biaxial
symmetry with mutually perpendicular easy, medium, and hard magnetic axes.
Previous calculations of the ground state tunnel splittings in the presence of
a magnetic field along the hard axis are extended, and the meaning of the
previously discovered oscillation of this splitting is further clarified
Oscillatory Tunnel Splittings in Spin Systems: A Discrete Wentzel-Kramers-Brillouin Approach
Certain spin Hamiltonians that give rise to tunnel splittings that are viewed
in terms of interfering instanton trajectories, are restudied using a discrete
WKB method, that is more elementary, and also yields wavefunctions and
preexponential factors for the splittings. A novel turning point inside the
classically forbidden region is analysed, and a general formula is obtained for
the splittings. The result is appled to the \Fe8 system. A previous result for
the oscillation of the ground state splitting with external magnetic field is
extended to higher levels.Comment: RevTex, one ps figur
Geometric-Phase-Effect Tunnel-Splitting Oscillations in Single-Molecule Magnets with Fourth-Order Anisotropy Induced by Orthorhombic Distortion
We analyze the interference between tunneling paths that occurs for a spin
system with both fourth-order and second-order transverse anisotropy. Using an
instanton approach, we find that as the strength of the second-order transverse
anisotropy is increased, the tunnel splitting is modulated, with zeros
occurring periodically. This effect results from the interference of four
tunneling paths connecting easy-axis spin orientations and occurs in the
absence of any magnetic field.Comment: 6 pages, 5 eps figures. Version published in EPL. Expanded from v1:
Appendix added, references added, 1 figure added, others modified
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